Yale graduate student Annie Le disappeared on Sept. 8, 2009, while working at campus lab. Technician Raymond Clark III, 24, was arrested Sept. 17, and charged with murdering the Le.

Defending a Yale lab technician charged with murder against what appears to be a mountain of forensic evidence might mean trying to convince jurors that the crime scene was contaminated because police didn't immediately shut down the lab where the victim was eventually found, legal experts said.

Raymond Clark III, 24, is charged with murder for the death of Yale graduate student Annie Le. She vanished from a research building in Yale's medical school complex on Sept. 8; her body was found hidden in a wall recess five days later, on what was to be her wedding day.

Police charged Clark after reviewing some 300 pieces of evidence, including DNA samples taken from Clark a day before he was arrested. His bond was set at $3 million, and he did not enter a plea. Officials reportedly found DNA from Le and Clark in the ceiling and in the recess where Le's body was found.

The evidence is so overwhelming that police believe they don't necessarily have to uncover Clark's motive for the killing to convince jurors of his guilt, according to a law enforcement official who spoke to The Associated Press on condition of anonymity because the investigation is ongoing.

That likely leaves Clark's attorneys with going after how that evidence was gathered — rather than what it showed — and have prosecutors defend their decision not to seal the lab building until Le's body was found.